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          <rev user="Gerard" timestamp="2023-12-24T18:37:01Z" comment="/* Phosphorylation on unusual amino acids */" contentformat="text/x-wiki" contentmodel="wikitext" xml:space="preserve">__NOTOC__
Welcome to WiKinome, a resource for of kinases and kinase signaling. Wikinome will include information on kinases and kinomes, with a focus on their evolution and function. We will include a page for every kinase family and subfamily: some are already fairly complete, like [[Kinase_Subfamily_CDK20|CDK20]] or [[Kinase_Subfamily_Erk7|Erk7]] but most are still under development or not-even written. We welcome contributors for all pages! We are also developing other pages on different kinase topics - see below for a partial listing.


===[[Introduction to Kinases]]===
A general introduction to protein kinases.

=== [[kinase classification|Kinase Classification]]===
Of the hundreds of kinases in the genome, how are they organized and classified?

===[[Protein Kinase Evolution]]===
Where did they come from, and how did they get to where they are now?

==Kinome Topics==
====[[Phosphorylation on unusual amino acids]]====
Assembling the scattered evidence for phosphorylation on histidine, aspartate, cysteine, lysine, and arginine.

====[[Tyrosine Phosphorylation in Dictyostelium]]====
Dictyostelium lacks typical tyrosine kinases (TK) but may have advanced receptor-based phosphotyrosine signaling.

====[[Phosphotyrosine binding domains]]====

====[[Evolution of SH2 domains]]====
Origin and development of the most important phospho-tyrosine binding domain.

====[[Phospho-Serine/Threonine binding domains]]====

====[[Human-Mouse Kinome Update]]====
Supporting material for our re-analysis of the human and mouse kinomes.

====[[Dual-Specificity Kinases]]====
Kinases that phosphorylate on Tyrosine as well as Serine/Threonine.

====[[Pseudokinases]]====
Proteins with kinase domains that lack predicted catalytic activity.

====[[Kinase Glossary]]====</rev>
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